Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2
نویسنده
چکیده
C. Celum, A. Wald, J.R. Lingappa, A.S. Magaret, R.S. Wang, N. Mugo, A. Mujugira, J.M. Baeten, J.I. Mullins, J.P. Hughes, E.A. Bukusi, C.R. Cohen, E. Katabira, A. Ronald, J. Kiarie, C. Farquhar, G.J. Stewart, J. Makhema, M. Essex, E. Were, K.H. Fife, G. de Bruyn, G.E. Gray, J.A. McIntyre, R. Manongi, S. Kapiga, D. Coetzee, S. Allen, M. Inambao, K. Kayitenkore, E. Karita, W. Kanweka, S. Delany, H. Rees, B. Vwalika, W. Stevens, M.S. Campbell, K.K. Thomas, R.W. Coombs, R. Morrow, W.L.H. Whittington, M.J. McElrath, L. Barnes, R. Ridzon, and L. Corey, for the Partners in Prevention HSV/HIV Transmission Study Team*
منابع مشابه
Daily acyclovir to decrease herpes simplex virus type 2 (HSV-2) transmission from HSV-2/HIV-1 coinfected persons: a randomized controlled trial.
BACKGROUND Daily suppressive therapy with valacyclovir reduces risk of sexual transmission of herpes simplex virus type 2 (HSV-2) in HSV-2-serodiscordant heterosexual couples by 48%. Whether suppressive therapy reduces HSV-2 transmission from persons coinfected with HSV-2 and human immunodeficiency virus type 1 (HIV-1) is unknown. METHODS Within a randomized trial of daily acyclovir 400 mg tw...
متن کاملAcyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
BACKGROUND Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce ...
متن کاملDaily Acyclovir Delays HIV-1 Disease Progression Among HIV-1/ HSV-2 Dually-Infected Persons: A Randomized Trial
Background—Well-tolerated medications that slow HIV-1 disease progression and delay initiation of antiretroviral therapy (ART) are needed. Most HIV-1-infected persons are dually-infected with herpes simplex virus type 2 (HSV-2). Daily HSV-2 suppression reduces plasma HIV-1 levels, but whether HSV-2 suppression delays HIV-1 disease progression is unknown. Methods—Within a randomized, placebo-con...
متن کاملManagement of herpes simplex virus type 2 infection in HIV type 1-infected persons.
Human immunodeficiency virus type 1 (HIV-1)-infected persons have high rates of herpes simplex virus type 2 (HSV-2) infection, ranging from 50% to 90% in studies of HIV-infected populations from different parts of the world. Genital herpes in persons with HIV type 1 (HIV-1) infection is associated with more-severe and chronic lesions, as well as increased rates of asymptomatic genital shedding ...
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Herpes simplex virus type 2 (HSV-2), the principal cause of genital herpes, infects the majority of human immunodeficien-cy virus type 1 (HIV-1)–infected persons worldwide [1]. HIV-1 is shed at high titers in genital ulcers caused by HSV-2 [2], and genital ulcer disease (GUD) increases the risk of HIV-1 transmission [3]. Asymp-tomatic HSV-2 reactivation (ie, viral shedding in the absence of gen...
متن کاملCan we reduce the spread of HIV infection by suppressing herpes simplex virus type 2 infection?
Overwhelming evidence from observational epidemiological studies indicates that herpes simplex virus type 2 (HSV-2) infection enhances the risk of acquiring HIV infection. Studies of genital shedding of HIV have suggested that HSV-2 infection also increases the onward transmission of HIV-1 by HIV/HSV-2 co-infected patients. Several randomized controlled trials were initiated to assess the impac...
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